Complement Factor I anticorps (C-Term)

N° du produit ABIN5514688

L’anticorps Lapin Polyclonal anti-Complement Factor I a été validé pour WB. Il convient pour détecter Complement Factor I dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc et Lapin.

Aperçu rapide pour Complement Factor I anticorps (C-Term) (ABIN5514688)

Antigène: Complement Factor I (CFI)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complement Factor I est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Complement Factor I anticorps

Épitope: C-Term

Séquence: AGTYDGSIDA CKGDSGGPLV CMDANNVTYV WGVVSWGENC GKPEFPGVYT

Homologie: Cow: 77%, Dog: 77%, Guinea Pig: 79%, Horse: 83%, Human: 100%, Mouse: 86%, Pig: 85%, Rabbit: 83%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against CFI. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CFI

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Complement Factor I

Antigène: Complement Factor I (CFI)

Autre désignation: CFI

Sujet: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alias Symbols: CFI, IF,

Protein Interaction Partner: GLP1R, CFH, C3,

Protein Size: 583

ID gène: 3426

NCBI Accession: NM_000204, NP_000195

UniProt: P05156

Pathways: Système du Complément